Based on these considerations, a basic knowledge of what a computer system is represents a fundamental building block for students in economics and business: all of them will interact daily with enterprise IS/Information Technologies (IT), some will even manage IS departments or IT companies, facing the complexity of decisions to be taken in this quickly evolving area with great technical and economical potentialities. For these reasons, the course is focused on the fundamental topics of the Information Systems, as Computer Systems, Computing Components and Architecture, Operating Systems, Communications and Networks, Databases, and Information security, including Appendices needed to refine basic pillars of the course.